Can Arizona win 2 in a row as a huge underdog? The Cardinals pulled off a shocking upset of the Dallas Cowboys as an 11-point home underdog last Sunday.
They'll be hitting the highway in Week 4 to take on another NFC behemoth, the San Francisco 49ers. Check out our Cardinals at 49ers Betting Preview, which has the live odds and our best bet!
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Live Odds for Arizona at San Francisco
At the time of this writing, most oddsmakers have the 49ers firmly entrenched as a 14-point favorite. The game isn't expected to be high scoring, as the total is currently sitting around 44 to 44.5 points.
If you think the Cardinals can shock the NFL world by winning the game outright, you can currently find odds of +580. That would be a nice ticket to cash after winning with Arizona on the moneyline last week at odds of +470.
Folks who would like to jump on the hometown Cardinals for only the first half can find +7.5 and a nice moneyline price of +325 at Desert Diamond Sports. If you expect Arizona to build on last week's positive momentum with a strong early showing, that may be the way to play this one.
Do the Cardinals Have a Chance?
Of course, Arizona has a shot at pulling off the upset! As the Cards reminded us all last week: Anything is possible in the NFL. Beating a 3-0 49ers team that has won 13 straight regular season games is a tall order, but stranger things have happened.
To stay in this game, Arizona has to find a way to slow down Christian McCaffrey. The former Standford star leads the league in rushing with 353 yards so far this season. Cards fans are hopeful that nose tackle Kevin Strong and defensive ends Jonathan Ledbetter and Leki Fotu can somehow contain CMC in the backfield.
Another key for Arizona will be the health of linebackers Josh Woods and Zaven Collins. Head coach Jonathan Gannon said that Collins should be good to go against San Fran. Unfortunately, Woods's status is still unclear, as he's been fighting an ankle injury for the past few weeks.
Best Bet: UNDER 44 Points
Both of these teams love to run the football, which should keep the clock churning and shorten the game. San Fran runs the ball at a 51.01% clip, which is the 3rd highest in the league. Arizona isn't too far behind that number, as Jonathan Gannon pounds the rock at a 49.12% rate.
Look for Gannon to try and establish the run as much as possible with James Connor. The former Pitt Panther is still one of the top running backs in the NFL and he's clearly Arizona's best offensive weapon. If the running game doesn't get any traction, Josh Dobbs is likely to check the ball down early and often to Connor to avoid the Niners pass rush.
All in all, this should be a low scoring affair. San Francisco's defense is one of the best in the league, so Arizona could have a tough time scoring more than a couple of touchdowns. Take the Under!
