| Saturday, August 22 at 1:36 PM | Spread | Money | Total |
| Toronto Blue Jays |  -1.5 (160) |  -104 |  O 6.5 (-120) |
| New York Yankees | +1.5 (-205) | -104 | U 6.5 (100) |
| Saturday, August 22 at 2:11 PM | Spread | Money | Total |
| Atlanta Braves | +1.5 (-152) |  +162 | O 8 (100) |
| Milwaukee Brewers | -1.5 (120) | -172 | U 7.5 (100) |
| Saturday, August 22 at 4:11 PM | Spread | Money | Total |
| Washington Nationals | +1.5 (-159) | +164 |  O 7.5 (-114) |
| Miami Marlins | -1.5 (118) | -175 | U 7.5 (-105) |
| Saturday, August 22 at 6:06 PM | Spread | Money | Total |
| St. Louis Cardinals | +1.5 (-190) | +138 | O 9 (100) |
| Philadelphia Phillies | -1.5 (135) | -145 | U 8.5 (102) |
| Saturday, August 22 at 7:06 PM | Spread | Money | Total |
| Tampa Bay Rays | -1.5 (125) | -122 | O 8 (-106) |
| Baltimore Orioles | +1.5 (-160) | +116 | U 8 (-125) |
| Saturday, August 22 at 7:06 PM | Spread | Money | Total |
| Los Angeles Angels | +1.5 (-155) | +153 | O 8 (-112) |
| Texas Rangers | -1.5 (122) | -160 | U 8 (-107) |
| Saturday, August 22 at 7:10 PM | Spread | Money | Total |
| New York Mets | +1.5 (-210) | +102 | O 8.5 (100) |
| Chicago White Sox | +1.5 (-205) | -106 | U 8 (-117) |
| Saturday, August 22 at 7:11 PM | Spread | Money | Total |
| Athletics | +1.5 (-111) | +215 | O 8 (-105) |
| Houston Astros | -1.5 (-120) | -232 | U 8 (-115) |
| Saturday, August 22 at 7:16 PM | Spread | Money | Total |
| San Francisco Giants | +1.5 (-130) | +190 | O 8 (-109) |
| Boston Red Sox | -1.5 (101) | -195 | U 8 (-111) |
| Saturday, August 22 at 7:16 PM | Spread | Money | Total |
| Chicago Cubs | +1.5 (-220) | +105 | O 7.5 (-106) |
| Seattle Mariners | +1.5 (-225) | -112 | U 7.5 (-114) |
| Saturday, August 22 at 7:16 PM | Spread | Money | Total |
| Detroit Tigers | -1.5 (150) | +100 | O 8.5 (-110) |
| Kansas City Royals | +1.5 (-190) | -104 | U 8.5 (-110) |
| Saturday, August 22 at 7:16 PM | Spread | Money | Total |
| Pittsburgh Pirates | +1.5 (-112) | +233 | O 7.5 (-110) |
| Los Angeles Dodgers | -1.5 (-118) | -250 | U 7.5 (-110) |
| Saturday, August 22 at 8:10 PM | Spread | Money | Total |
| Cincinnati Reds | +1.5 (-162) | +158 | O 8.5 (100) |
| Arizona Diamondbacks | -1.5 (118) | -166 | U 8 (-117) |
| Saturday, August 22 at 8:11 PM | Spread | Money | Total |
| Cleveland Guardians | -1.5 (100) | -134 | O 11 (-104) |
| Colorado Rockies | +1.5 (-130) | +132 | U 11 (-115) |
| Saturday, August 22 at 8:41 PM | Spread | Money | Total |
| Minnesota Twins | +1.5 (-177) | +126 | O 8.5 (-103) |
| San Diego Padres | -1.5 (143) | -134 | U 8 (100) |
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