USC vs Oregon Betting Guide: 3 Player Props and Best Bet for November 22

Saturday, September 5 at 3:30 PM	Spread	Money	Total
Boise State Broncos	+25 (-110)	+1500	O 53.5 (-110)
Oregon Ducks	-25 (-113)	-3600	U 52.5 (-108)

The Big Ten’s big battle will happen on Saturday as the No. 15-ranked USC Trojans (8-2, 6-1 Big Ten) head north to Autzen Stadium to face the No. 7-ranked Oregon Ducks (9-1, 6-1 Big Ten).

USC has answered the bell multiple times this season. The Trojans are 2-2 against ranked opponents, winning both games the California-based school has hosted while losing their two road matchups.

The same isn’t true for Oregon. The Ducks have played only two ranked teams, losing to an undefeated Indiana squad and barely defeating Iowa on the road. Oregon is looking for a second consecutive Big Ten title and CFP appearance.

Is the third time the charm for USC, finally winning on the road against a ranked opponent? We’ll answer that question and provide bettors with our favorite three player props below.

Oregon Ducks QB Dante Moore 228.5 Passing Yards

Dante Moore has enjoyed a sensational sophomore season. The 6-foot-3 quarterback has completed 72.8 percent of his passes for 2,190 yards, 21 touchdowns, and only five interceptions.

His opponent on Saturday hasn’t allowed an opponent to throw for more than 207 yards since yielding over 300 to Illinois’ Luke Altmyer. Moore passed for 306 yards last week against Minnesota. That should give bettors confidence to take the over on Moore’s passing prop total on Saturday.

USC Trojans WR Makai Lemon UNDER 93.5 Receiving Yards

Junior receiver Makai Lemon has had a spectacular season. The 5-foot-11 athlete has caught 71 passes for 1,090 yards and eight scores in 2025, leading his team in all three categories. He’s also third in the nation in receiving yards at the FBS level.

Still, only Indiana’s Elijah Sarratt has eclipsed the century receiving mark against the Ducks’ defense in their last six games. Lemon will get his opportunities, but bettors should expect the receiver to fall just short of his receiving prop totals on Saturday.

Oregon Ducks RB Noah Whittington OVER 83.5 Rushing Yards

Oregon running back Noah Whittington is having a strong season. The senior has amassed an incredible 8.2 yards per rush, converting his 76 carries into 623 yards and five touchdowns. He’s also caught 11 passes for 48 yards, scoring once through the air.

The Trojans have struggled against strong running attacks. USC has allowed over 130 rushing yards to each of its past four opponents. Whittington alone could add to that total on Saturday. Expect him to cover this high player prop bet total.

Best Bet: USC (+10)

USC has made the most of its difficult schedule, earning its spot among the CFP contenders in 2025. A road win against Oregon would likely cement the team’s status as a front-runner for the playoffs.

Don’t expect the Trojans to win this game, however. Autzen Stadium is a difficult place to play, and Oregon knows a playoff berth is likely on the line. Take the Ducks to win this contest, but bettors should expect the final margin to less. A final score with USC losing by a touchdown or less is the likely outcome.