NFL Week 6 Sunday Watch Guide: London Breakfast Football, a 54.5 Shootout, and Lamar Jackson’s Replacement Under the Lights

Sunday’s NFL slate kicks off before most of the East Coast has finished its first cup of coffee and doesn’t let up until the final whistle in Atlanta nearly 12 hours later. Between a London breakfast game, a shootout waiting to happen in the desert, and a Sunday Night Football storyline nobody saw coming a week ago, this is a full day of television worth clearing your schedule for. Here’s what to watch, what’s at stake, and where the smart money is leaning.

Eagles-Jaguars Kicks Off the Day from London

Set your alarm, because the first game of the day comes from Tottenham Hotspur Stadium at 9:30 AM ET. The Jaguars travel across the Atlantic as 7.5-point favorites with the total sitting at 41.5, which tells you plenty about how banged up Philadelphia looks heading into this one. The Eagles are missing both starting outside receivers — DeVonta Smith (hamstring) and Hollywood Brown (ankle) — leaving an already thin passing attack even thinner. Saquon Barkley is trending toward playing through a knee issue, and Dallas Goedert is working his way back from his own knee injury, so Philly’s offense could look patchwork early on London time.

Jacksonville, at 3-1, gets to play this one as the neutral-site “road” team that’s really more like a home game given how lopsided the betting line is. A big early cover for the Jaguars would set the tone for the rest of the day and give East Coast viewers a jolt before their actual breakfast is even on the table.

Lions at Cardinals: The Shootout Everyone’s Circling

If you only watch one afternoon game for pure entertainment value, make it this one. Detroit heads to State Farm Stadium as 5.5-point favorites, but it’s the total — 54.5, the highest on the entire slate — that has everyone’s attention. Both offenses have been lighting up scoreboards, and Arizona’s attack has quietly become appointment viewing behind quarterback Jacoby Brissett and emerging receiver Michael Wilson, who’s turned into Brissett’s clear go-to target. Add in tight end Trey McBride, one of the better pass-catching tight ends in the league, and the Cardinals have the pieces to keep pace with just about anybody through the air.

Detroit brings its own high-powered attack and will lean on its usual balance of ground game and explosive plays downfield. With both defenses banged up on the back end, this has shootout written all over it — the kind of game where neither sideline is particularly interested in playing it safe, and the scoreboard operator earns their paycheck. If you’re building a same game parlay around this one, the passing props practically write themselves.

Bears at Packers Brings Rivalry Theater to Lambeau

There’s no storyline in the NFL quite like Bears-Packers, and this year’s trip to Lambeau Field has real juice behind it. Chicago is a slight 1.5 to 2.5-point favorite on the road, a sentence that still feels strange to type given the history between these two, and the total sits at 45.5. Both teams have things to prove this season, and nothing sharpens focus like division pride and decades of bragging rights on the line. Whatever the records say entering Sunday, this one tends to play faster, tougher, and nastier than the number suggests — exactly what you want from an early-afternoon window game.

Ravens at Falcons Headlines Sunday Night with a Twist

The marquee Sunday Night Football matchup got a major plot twist this week: Lamar Jackson has been ruled out with the ankle injury he suffered against Tennessee, which means Tyler Huntley steps back into the starting role for Baltimore. Huntley has a track record of winning games as a fill-in, and the Ravens have shown confidence in him before, but asking him to go on the road against a desperate Falcons team under the lights is a tall order. Atlanta, now a 3 to 3.5-point favorite at home with the total at 43.5, will lean on a defense that’s been one of the stingier units in the league against the pass this season.

Add in question marks around Zay Flowers (foot) and Marlon Humphrey (calf/hamstring) for Baltimore, and this primetime game suddenly has a very different complexion than it did a week ago. It’s the kind of late-season-feeling drama you don’t expect in Week 6, and it makes Ravens-Falcons must-watch simply to see how Baltimore adapts on the fly.

This Week’s Best Bets

Across a jam-packed slate, these four games stand out as the best combination of drama and betting value heading into Sunday.

• Eagles @ Jaguars: Jaguars -7.5
• Lions @ Cardinals: Over 54.5
• Bears @ Packers: Bears -1.5/-2.5
• Ravens @ Falcons: Falcons -3/-3.5

With a London breakfast game, a projected shootout in the desert, a heated rivalry at Lambeau, and a primetime quarterback change on the biggest stage, Sunday’s slate has something for every kind of fan to watch — and plenty to bet on while you’re doing it.