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NFL Week 2 Preview: Lives Odds and Brief Breakdown of Each Matchup

Earnest Horn
Written by Earnest Horn
September 11, 2024
NFL Week 2 Lives Odds and Breakdown of Each Matchup

The first week of NFL action proved that oddsmakers are guessing just as much as you were last week. Vegas was only 9-7 overall in setting the lines for the season-opening games, showing that even people who get paid to do this can succumb to preseason hype.

There’s no hype here as we review the NFL’s Week 2 odds. Enjoy all of the action this week! Good luck!

Sunday, October 6 at 1:00 PMSpreadMoneyTotal
Buffalo Bills
-1.5
(-102)
-110
O 47.5
(-105)
Houston Texans
+1.5
(-120)
+100
U 47.5
(-115)

Bills at Dolphins

The Miami Dolphins (1-0) face the Buffalo Bills (1-0) in a critical AFC East showdown, where both teams are battling for divisional supremacy. With the Dolphins' high-powered offense going up against the Bills' stingy defense, this game could have significant playoff implications.

Sunday, October 6 at 8:20 PMSpreadMoneyTotal
Dallas Cowboys
+2.5
(-110)
+118
O 44
(-108)
Pittsburgh Steelers
-2.5
(-115)
-135
U 43.5
(-102)

Saints at Cowboys

The New Orleans Saints (1-0) face the Dallas Cowboys (1-0) in a thrilling matchup, with the Saints coming off a dominant Week 1 performance where they scored the most points in the league. The Cowboys' defense will be tested to slow down the Saints' high-powered offense and build on their early-season success.

Sunday, October 13 at 4:26 PMSpreadMoneyTotal
Detroit Lions
-3
(-110)
-148
O 52
(-110)
Dallas Cowboys
+3
(-115)
+130
U 51.5
(-105)

Bucs at Lions

The Tampa Bay Buccaneers (1-0) take on the Detroit Lions (1-0) in a matchup of old NFC North rivals, both aiming to solidify their playoff aspirations. With both teams showing promise early in the season, this game could be pivotal in shaping the postseason race.

Sunday, October 6 at 1:00 PMSpreadMoneyTotal
Indianapolis Colts
+3
(-120)
+130
O 46.5
(-105)
Jacksonville Jaguars
-3
(-105)
-148
U 45.5
(-110)

Colts at Packers

The Indianapolis Colts (0-1) face the Green Bay Packers (0-1) in a crucial matchup, with the Packers navigating the absence of quarterback Jordan Love, who is out 3-6 weeks due to injury. The Colts will look to capitalize on Green Bay’s uncertainty at quarterback as both teams fight to stay competitive in their divisions.

Sunday, October 13 at 1:01 PMSpreadMoneyTotal
Indianapolis Colts
-1.5
(-105)
-115
O 42
(-108)
Tennessee Titans
+1.5
(-115)
-102
U 41.5
(-110)

Jets at Titans

The New York Jets (0-1) take on the Tennessee Titans (0-1) in a compelling matchup, where the Titans’ evolving offense will face a stiff test against the Jets’ physical defense. Both teams are eager to build momentum, making this a crucial game for playoff positioning early in the season.

Sunday, October 6 at 9:30 AMSpreadMoneyTotal
New York Jets
+3
(-120)
+124
O 40.5
(-105)
Minnesota Vikings
-3
(100)
-138
U 40
(-110)

49ers at Vikings

The San Francisco 49ers (1-0) take on the Minnesota Vikings (1-0) in a key matchup, with the 49ers' offense facing uncertainty as star running back Christian McCaffrey’s status remains in doubt. The Vikings will look to exploit any potential weakness in the 49ers' ground game as both teams aim to make a statement early in the season.

Sunday, October 6 at 4:25 PMSpreadMoneyTotal
New York Giants
+6.5
(-110)
+245
O 43.5
(-110)
Seattle Seahawks
-6.5
(-120)
-275
U 43.5
(-110)

Seahawks at Pats

The Seattle Seahawks (1-0) face the New England Patriots (1-0) in a defensive showdown, with sportsbooks projecting the lowest total points for Week 2 at 37.5. Both teams will rely on their defenses to control the game, as scoring opportunities are expected to be limited in this affair.

Sunday, October 6 at 1:00 PMSpreadMoneyTotal
Cleveland Browns
+3.5
(-120)
+145
O 43.5
(-110)
Washington Commanders
-3.5
(-105)
-166
U 43.5
(-110)

Giants at Commanders

The New York Giants (0-1) and Washington Commanders (0-1) clash in a pivotal NFC East matchup, where both teams are looking to make a statement early in the season. With divisional rivalries intensifying, this game is crucial for both teams to set the tone for the remainder of the year.

Sunday, October 6 at 1:00 PMSpreadMoneyTotal
Carolina Panthers
+4
(-112)
+175
O 41.5
(-105)
Chicago Bears
-4
(-115)
-192
U 41
(-112)

Chargers at Panthers

The Los Angeles Chargers (1-0) take on the Carolina Panthers (0-1) as the Panthers come off a Week 1 performance where they allowed the most points in the league. The Chargers will look to capitalize on this defensive vulnerability and build on their own early-season momentum.

Sunday, October 6 at 1:00 PMSpreadMoneyTotal
Cleveland Browns
+3.5
(-120)
+145
O 43.5
(-110)
Washington Commanders
-3.5
(-105)
-166
U 43.5
(-110)

Browns at Jags

The Cleveland Browns (0-1) face the Jacksonville Jaguars (0-1) in a critical matchup, with both teams looking to avoid falling to 0-2. Historically, teams starting 0-2 have a tough road ahead, with only 31 of the 270 since 1990 making it to the playoffs, adding extra urgency to this game.

Sunday, October 6 at 1:00 PMSpreadMoneyTotal
Baltimore Ravens
-2.5
(-120)
-135
O 49.5
(-110)
Cincinnati Bengals
+2.5
(-110)
+120
U 48.5
(-105)

Raiders at Ravens

The Las Vegas Raiders (0-1) take on the Baltimore Ravens (0-1) in a matchup where the Raiders will aim to challenge the Ravens' dynamic defense with their improving offense. Both teams are looking to make a statement and secure a crucial win early in the season to build momentum for the playoffs.

Sunday, October 6 at 4:05 PMSpreadMoneyTotal
Arizona Cardinals
+7.5
(-115)
+290
O 50
(-108)
San Francisco 49ers
-7.5
(-110)
-350
U 49.5
(-110)

Rams at Cardinals

The Los Angeles Rams (0-1) face the Arizona Cardinals (0-1) in a key NFC West showdown, with both teams eager to assert themselves in a competitive division. The matchup will highlight the Rams' potent offense against the Cardinals' defensive strategies, as each team aims to gain an early edge in the division race.

Sunday, October 6 at 8:20 PMSpreadMoneyTotal
Dallas Cowboys
+2.5
(-110)
+118
O 44
(-108)
Pittsburgh Steelers
-2.5
(-115)
-135
U 43.5
(-102)

Steelers at Broncos

The Pittsburgh Steelers (1-0) take on the Denver Broncos (0-1) with quarterback Justin Fields expected to start for the Steelers. Fields' second game under center would be a focal point of this matchup as he looks to lead the Steelers' offense against the Broncos' improving defense in a crucial matchup.

Sunday, October 6 at 1:00 PMSpreadMoneyTotal
Baltimore Ravens
-2.5
(-120)
-135
O 49.5
(-110)
Cincinnati Bengals
+2.5
(-110)
+120
U 48.5
(-105)

Bengals at Chiefs

The Cincinnati Bengals (0-1) visit the Kansas City Chiefs (1-0) in a highly anticipated rematch of the 2022 AFC Championship game. Both teams are eager to settle the score from their previous playoff encounters, with the Chiefs looking to assert their dominance and the Bengals aiming for redemption.

Sunday, October 6 at 1:00 PMSpreadMoneyTotal
Carolina Panthers
+4
(-112)
+175
O 41.5
(-105)
Chicago Bears
-4
(-115)
-192
U 41
(-112)

Bears at Texans

The Chicago Bears (1-0) visit the Houston Texans (1-0) as the NFC North squad continues their search for their first offensive touchdown of the season. No. 1 overall pick Caleb Williams will aim to spark their struggling offense in his first primetime contest. The Texans will look to capitalize on the Bears' offensive woes and secure a crucial win at home.

Falcons at Eagles

The Atlanta Falcons (0-1) take on the Philadelphia Eagles (1-0) in a thrilling Monday Night Football matchup. Both teams are eager to make a statement in prime time, with the Falcons looking to capitalize on their recent momentum and the Eagles aiming to solidify their status as one of the NFC's top contenders.

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