Heading into Sunday’s game, the AFC South has two teams atop the division. Those two squads will meet when the Indianapolis Colts (8-4) head south to take on the Jacksonville Jaguars (8-4) at 1 p.m.
Indianapolis was solely in the driver’s seat in the AFC South until recently. After starting the year with a 7-1 record, the Colts have dropped three of their last four outings, including last week’s 20-16 defeat against the Houston Texans.
Jacksonville is headed in the opposite direction. A mid-season slump left the Jaguars with a 5-4 record, but the squad has rebounded with three straight wins to force a tie at the top of the AFC South.
Can the Colts continue dominating the AFC South, or will Jacksonville claim sole possession of first place in the division? We’ll cover that and provide bettors with our top three player props for Sunday’s contest.
Jacksonville Jaguars QB Trevor Lawrence OVER 220.5 Passing Yards
In his fifth year, Jacksonville quarterback Trevor Lawrence remains among the league’s top talents despite his subpar showing this year. He’s completed just under 60 percent of his passes for 2,636 yards, 16 touchdowns, and 11 interceptions.
Passing teams have lit up the stat sheet against the Colts this season. Indy has surrendered at least 275 yards on four occasions in 2025, including the team’s past two outings. Expect Lawrence to top his 220.5-yard prop on Sunday, finishing with at least 221 yards for the eighth time in 2025.
Indianapolis Colts RB Jonathan Taylor UNDER 94.5 Rushing Yards
Indianapolis features the league’s top rusher in Jonathan Taylor. The 5-foot-10 running back has a league-best 1,282 rushing yards, scoring 15 rushing touchdowns on 226 total carries. He’s averaging 5.7 yards per rush this season.
Taylor’s opponent on Sunday has been among the league’s best rushing defenses. Thus far, the Jaguars haven’t allowed a single back to surpass the 90-yard mark this season. Taylor is certainly the player to accomplish that task, but bettors should take the under on this rushing prop total.
Indianapolis Colts TE Tyler Warren OVER 51.5 Receiving Yards
Rookie tight end Tyler Warren is having a strong debut in the NFL. The 6-foot-6 target is second on the team with 58 receptions, 684 receiving yards, and four touchdowns. He’s third among all tight ends this season in receiving yards, trailing only Arizona’s Trey McBride and Kansas City’s Travis Kelce.
Jacksonville has surrendered big-time yardage to players at this position in 2025. The Jaguars have allowed seven tight ends – including both McBride and Kelce – to finish with at least 47 yards this season. Warren will add his name to the list, covering this receiving prop bet on Sunday.
| Sunday, September 13 at 1:00 PM | Spread | Money | Total |
| Cleveland Browns |  +7.5 (-114) |  +325 | O 40.5 (-108) |
| Jacksonville Jaguars |  -7.5 (-115) |  -340 | U 40.5 (-115) |
Best Bet: Jacksonville (+1.5)
Oddsmakers believe Sunday’s game will come down to the wire, giving the Colts a 1.5-point advantage. The irony is that every game since 2009 has been decided by three or more points in this twice-a-year series.
Here’s another tip that should clue bettors into taking Jacksonville: The Colts have not won a road game against the Jaguars since 2014. Don’t expect that to change this year, either. Take Jacksonville to cover the spread and win this AFC South matchup.
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