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49ers vs Rams: 3 Player Props and Best Bet for Thursday Night Football

By Earnest Horn Updated October 2, 2025
49ers vs Rams 3 Player Props and Best Bet for Thursday

The NFC West steps into the primetime spotlight during Week 5 when the San Francisco 49ers (3-1) head south to face the Los Angeles Rams (3-1) on Thursday night.

San Francisco is looking to pick up its third NFC West win of the season on Thursday. The 49ers were knocked from the unbeaten ranks last Sunday, dropping a 26-21 decision to the Jacksonville Jaguars.

Los Angeles has yet to face another divisional foe this season. The Rams nearly entered the contest undefeated, but a 33-26 loss to the Philadelphia Eagles on the road kept Los Angeles from chasing history.

Can the 49ers stay undefeated in the NFC West, or will Los Angeles claim its fourth straight victory over San Francisco? We’ll cover that and provide bettors with our top three player props for this game.

PlayerPropPrice
Matthew StaffordOver 244.5 Pass Yards
Matthew StaffordUnder 246.5 Pass Yards

Los Angeles Rams QB Matthew Stafford OVER 234.5 Passing Yards

Rams quarterback Matthew Stafford continues to shine this season. Through four games, he’s second in the NFL with 1,114 passing yards, adding eight touchdowns and two interceptions to his totals.

San Francisco has found ways to contain him over their past few outings, limiting him to under 240 yards on three of the past four matchups. Still, it’s hard to go against the hot hand. Bettors should take him to finish slightly above the 234.5-yard passing mark on Thursday as he covers his prop total.

PlayerPropPrice
Christian McCaffreyOver 61.5 Rush Yards
Christian McCaffreyUnder 62.5 Rush Yards

San Francisco 49ers RB Christian McCaffrey UNDER 64.5 Rushing Yards

The injury bug has bitten several of the 49ers’ top players. Quarterback Brock Purdy is questionable for this game, and one of his top receivers – George Kittle – remains sidelined. One player San Francisco does have is running back Christian McCaffrey.

McCaffrey has 530 total yards heading into this game, although most of those have come in the passing attack. The 2017 first-round draft pick is averaging just over three yards per rush, and he’s eclipsed the 64-yard mark just once this season. Whether Purdy is available or not, bettors should take the under on his rushing prop for Thursday’s contest.

PlayerPropPrice
Puka NacuaOver 91.5 Reception Yards
Puka NacuaUnder 94.5 Reception Yards

Los Angeles Rams WR Puka Nacua UNDER 95.5 Receiving Yards

Third-year receiver Puka Nacua is off to a red-hot start for the Rams. The 6-foot-2 athlete has made 10 or more receptions in three of the team’s four outings, and last week’s 13-catch, 170-yard explosion pushed him to the top of the NFL receiving board.

For the year, he’s hauled in an impressive 42 receptions for 503 yards, scoring one touchdown. History shows he’s been able to pick up yards against the 49ers with ease, too. In three matchups, Nacua has finished above 96 yards twice.

Can he make it a third time on Thursday? Bettors should expect the 49ers will focus their game plan on slowing him down. Despite his incredible start, individuals should take the under on this player prop wager.

Sunday, November 8 at 1:00 PMSpreadMoneyTotal
Los Angeles Rams
-4.5
(-118)
-225
O 48
(-110)
Washington Commanders
+4.5
(-112)
+194
U 47.5
(-108)

Best Bet: Under 45.5 Points

The oddsmakers have made Los Angeles a seven-point favorite for this NFC West rivalry game. Yet the last three outings have been closer contests, each being decided by less than one touchdown.

Picking the Kittle-less 49ers to pull off the upset doesn’t add up, either. That’s why bettors should turn to another line to earn some cash from this contest. Savvy bettors will expect this to be a defensive contest, making the under for the 46.5-point combined total score the best bet for Thursday’s game.

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