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49ers vs Eagles Betting Preview: 2 Player Prop Predictions and Best Bet

By Jaden Vann Updated January 7, 2026
49ers vs Eagles 2 Player Prop Predictions and Best Bet

The San Francisco 49ers have a chip on their shoulder as they travel to Philly this weekend to take on the Eagles. San Francisco has been nearly unstoppable with Purdy under center during the second half of the season, and with CMC healthy, this should be a closer game than the books and experts expect.

Sunday, September 13 at 4:25 PMSpreadMoneyTotal
Washington Commanders
+5.5
(-110)
+195
O 47.5
(-107)
Philadelphia Eagles
-5.5
(-110)
-215
U 46.5
(-110)

Best Bet: 49ers +4.5

Four and a half points for a Purdy/Shanahan/McCaffrey offense? I’m rolling with the San Francisco 49ers to make this a tight matchup in Philadelphia on Sunday afternoon. The 49ers won six straight with Purdy before dropping their final regular-season game against the Seahawks.

This still feels as if it has ‘revenge matchup’ material if we look back on that 2022 NFC Championship game matchup, where Purdy was hurt and the 49ers were left virtually Quarterback-less. This spread favors the Eagles too much as a team that only scored 22.3 PPG this season and finished the year just 3-4.

Live player props data coming soon for Christian McCaffrey.

Christian McCaffrey (SF) Anytime TD Scorer

Shanahan and the 49ers will take no chances in the red zone against this Eagles defense. McCaffrey scored in six straight games before the 9ers’ Week 18 loss to Seattle. On the year, he has 10 rush TDs and 7 receiving TDs as the conductor of this offense.

With Brock Purdy finishing the year at an MVP caliber level, I’m banking on a handful of red zone trips and a CMC score – something that came in 12 of 17 games this season and in every 49ers playoff game spanning from 2022-2023.

Live player props data coming soon for DeVonta Smith.

DeVonta Smith (PHI) UNDER 4.5 Receptions

Smith recorded four receptions in each of Philly’s four playoff wins last season en route to a Super Bowl victory. He is the WR2 behind A.J. Brown and in the red zone might even be considered the 3rd or 4th option behind Brown, Goedert, and Barkley within this offense.

Between 3rd down tush-pushes and Barkley due for a big role against this 49ers defense, once again it seems as if opportunities could be limited for Smith who still remains one of the best WR2s in the game but with the game scheme and Hurts’ style, it will be difficult to reach this mark.

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